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A STUDY ON THE ANTIMICROBIAL SUSCEPTIBILITY OF ORAL MICROFLORA IN CHILDREN SUSCEPTIBLE TO INFECTIVE ENDOCARDITIS

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Abstract

°á·Ð
º» ¿¬±¸´Â °¨¿°¼º ½É³»¸·¿°¿¡ ÀÌȯµÇ±â ½¬¿î ¼Ò¾Æµé¿¡°Ô ¿¹¹æÀû ¸ñÀûÀ̳ª Ä¡·á ¸ñÀûÀ¸·Î
Ç×±ÕÁ¦¸¦ ¼±Åà ÇÒ ¶§ ¿Ã¹Ù¸¥ ÁöÇ¥¸¦ Á¦½ÃÇϱâ À§ÇÏ¿© ½ÉÀ庴 ¾î¸°ÀÌ 20¸í°ú °Ç°­ÇÑ ¾î¸°ÀÌ
20¸íÀ» D»óÀ¸·Î ±¸°­³» ¼¼±ÕÃÑ µ¿Á¤ ¹× Ç×±ÕÁ¦ °¨¼ö¼º °Ë»ç¸¦ ½ÃÇàÇÑ °á°ú ´ÙÀ½°ú °°Àº °á
·ÐÀ» ¾ò¾ú´Ù.
1. ½ÉÀ庴 ¾î¸°ÀÌ¿Í °Ç°­ÇÑ ¾î¸°ÀÌ »çÀÌ¿¡ ±¸°­³» ¼¼±ÕÃÑÀÇ ±ÕÁÖ Á¾·ù¿¡´Â Å« Â÷ÀÌ°¡ ¾ø
¾ú´Ù.
2. ½ÉÀ庴 ¾î¸°ÀÌ(°íÂû±º)¿Í °Ç°­ÇÑ ¾î¸°ÀÌ(ÂüÁ¶±º)¿¡¼­ S. viridans¿¡ ´ëÇÑ Ç×±ÕÁ¦ °¨¼ö¼º
°Ë»ç °á°ú Erythromycin, Oxacillin, Ciprofloxacin, Penicillin, Ampicillin, Clindamycin,
Gentamicin, CephlothinÀÇ ¼øÀ¸·Î °¨¼ö¼º ÀÌ ³ô°Ô ³ªÅ¸³µÀ¸¸ç, Imipenem°ú VancomycinÀº
µÎ ±º¿¡ ¸ðµÎ 100%ÀÇ °¨¼ö¼ºÀ» º¸¿´´Ù.
3. °íÂû±º°ú ÂüÁ¶±º¿¡¼­ Neisseria°ú ±ÕÁֵ鿡 ´ëÇÑ Ç×±ÕÁ¦ °¨¼ö¼º °Ë»ç °á°úÀÇ
Clindamycin, Erythromycin, Vancomycin, Penicillin, Ciprofloxacin, Cephlothin, Gentamicin
¼øÀ¸·Î °¨¼ö¼ºÀÌ ³ô°Ô ³ªÅ¸³µ°í, ImipenemÀº µÎ ±º¿¡ ¸ðµÎ 100%ÀÇ °¨¼ö¼ºÀ» º¸¿´´Ù.
À̻󿡼­ Ä¡°ú, ±¸°­¿Ü°ú ½Ã¼ú½Ã ¼¼±Õ¼º ½É³»¸·¿°ÀÇ ¿¹¹æÀ» À§ ¹Ì±¹½ÉÀåÇÐȸ°¡ ÃßõÇÏ´Â
±âº» ¾àÁ¦µéÀº Ç×±ÕÁ¦ °¨¼ö¼ºÀÌ ÀüÀ¸·Î ³·°Ô ³ªÅ¸³ª ÀÏÂ÷ ¼±Åà ¾àÁ¦·Î´Â ºÎÀûÀýÇϸ®¶ó »ç·á
µÇ¸ç, ImipenemÀº °¡Àå ¿ì¼öÇÑ Ç×±Õ·ÂÀ» °¡Áø ¾àÁ¦·Î Æò°¡µÇ¾ú´Ù.
±×·¯¹Ç·Î ¼¼±Õ¼º ½É³»¸·¿°À» ¿¹¹æÇÒ ¸ñÀûÀ¸·Î Ç×±ÕÁ¦¸¦ ¼±Åà ¶§´Â ±¸°­³» ¼¼±ÕÃÑ¿¡°Ô ´ë
ÇÑ surveillant culture¸¦ »çÀü¿¡ ½ÃÇàÇÏ¿© °³°³ÀÇ È¯ÀÚ°¡ °¡Áö°í ÀÖ´Â ±¸°­³» »óÁÖ±ÕÀÇ ´ëÇÑ
Ç×±ÕÁ¦ °¨¼ö¼ºÀ» °í·ÁÇÏ¿© Ä¡°úÄ¡·á¿¡ ÀÓÇؾ߰ڴÙ.

The present study has been performed to evaluate 20 cardiopathy children and 20
healthy children's oral micorbes at the point of antimicrobial susceptibilities for
antimicrobial prophylaxis to prevent bacterial endocarditis.
The results were as follows:
1. Both groups had similar oral microbes.
2. The antimicrobial susceptibility of S. viridans were: Penicillin< Oxacillin<
Ampicillin< Cephlothin< Erythromycin< Clindamycin< Gentamicin< Ciprofloxacin<
Vancomycin=Imipenem. The cardiopathy group was slightly lower antimicrobial
susceptibility rates than healthy group.
3. The antimicrobial susceptibility of Neisseriaceae were: Clindamycin< Erythromycin<
Vancomycin< Penicillin< Gentamicin< Oxacillin< Cephlothin< Ciprofloxacin< Imipenem.
The antibiotics of bacterial endocarditis antibiotic prophylaxis regimens for dental
procedures according to the American Heart Association were generally lower
antimicrobial susceptibilities, so they are considered inadequate for the first selective
antibiotics and Imipemim was best suitable antimicrobial.
Conclusively, when choose antimicrobials for treatment or antimicrobial prophylaxsis
for bacterial endocarditis, surveillant culture must be performed to evaluated personal
antimicrobial susceptibilities of intraoral microbes for proper antimicrobial choice for
dental proceduers.

Infective endocarditis; S. viridans; antimicrobial susceptibility of the reproducibility of the frontal and; major concern related to the accuracy of three dimensional measurement; Further investigation of anatomical investigation of facial skeleton w;

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